Results
Publications
Tong Y, Becker M, Schierloh U, Natividade da Silva F, Haataja L, Cai Y, Patel K A, Kobaisi F, Mirshahi U L, Colclough K, Shabab Javed M, Wakeling M N, Fantuzzi F, Lytrivi M, Sawatani T, Arroyo M N, Yi X, Vinci C, Montaser H, Pachera N, Otonkoski T, Igoillo-Esteve M, Scharfmann R, Hattersley A T, Arvan P, De Beaufort C, Cnop M.
A new form of diabetes caused by INS mutations defined by zygosity, stem cell and population data
EMBO Molecular Medicine 2026.
Fu C, Li T, Hao Y, Lin Y, Qiu Y, Jia Y, Yang J, Liu B, Hua D, Wang C, Chen T, Piron A, Cnop M, Ni Q, Zheng J, Ning G, Gu Y.
Declining FXR expression coordinates neonatal beta cell mass development with microbial bile acid metabolism maturation in mice
Diabetologia 2026.
Michel M, Taebnia N, Lauschke V M.
Facilitated DNA damage repair as an emerging therapeutic strategy for inflammatory and fibrotic diseases
RSC Chemical Biology 2026.
Chen S-Y, Lekka C, Lemvig J, Yi X, Cnop M, Marchetti P, Marselli L, Xia J, Madsen J G S, Rodriguez-Calvo T, Richardson S J, Johnson J D, MacDonald P E.
From pancreas and islet resources to diabetes insights
Diabetologia 2026.
Van Mulders A, Willems L, Coenen S, Bourgeois S, Yi X, Tong Y, Leuckx G, Heremans Y, Pierreux J, Degroote L, Sawatani T, Vinci C, Ates G, Massie A, Carlotti F, de Koning E, Mandrup-Poulsen T, Zelinsky C, Goderis S, Ghesquière B, Scharfmann R, Cnop M, De Leu N, Staels W.
Iron deficiency induces maturation-dependent loss of pancreatic β-cells
Nature Communications 2026.
Bautista A, Fernandez-Tardon G, Rodríguez-Suárez M M, Tardon A, Bravo N, Garí M, Grimalt J O, Llorca M, Farré M.
Per- and Polyfluoroalkyl Substances in Urine Samples from Eight-Year-Old Children Living in Northwest Spain
Molecules 2026.
Ahonen M H, Konzack A, Smutny T, Pavek P, Hakkola J, Hukkanen J.
Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression
Basic & Clinical Pharmacology & Toxicology 2026.
Youhanna S, Taebnia N, Liang Y, Cheng N, Wang Y, Michel M, Lauschke V M.
Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays
Advanced Biology 2026.
Berrada L, Crenier L, Lytrivi M, Burniat A, Motulsky E, Cnop M.
Real-world performance of an AI system for diabetic retinopathy screening
Scientific Reports 2026.
Virgilio E, Tielens S, Bonfield G, Nian F-S, Sawatani T, Vinci C, Govier M, Montaser H, Lartigue R, Arunagiri A, Liboz A, Da Silva F N, Lytrivi M, Papadopoulou T, Wakeling M N, Russ-Silsby J, Bowman P, Johnson M B, Laver T W, Piron A, Yi X, Fantuzzi F, Hendrickx S, Igoillo-Esteve M, Santacreu B J, Suntharesan J, Ghildiyal R, Hegde D, Shah N, Acar S, Dönmez B Ö, Özkan B, Mohsin F, Talaat I M, Abbas M T, Abbas O T, Alghamdi H A, Kandemir N, Flanagan S E, Scharfmann R, Arvan P, Raoux M, Nguyen L, Hattersley A T, Cnop M, De Franco E.
Recessive TMEM167A variants cause neonatal diabetes, microcephaly, and epilepsy syndrome
Journal of Clinical Investigation 2026.
Lauschke V M, Ingelman-Sundberg M.
The Evolving Landscape of Pharmacogenomics: Current Achievements and Future Directions
Pharmacological Reviews 2026.
Suleiman M, Sawatani T, Tesi M, Yi X, Papadopoulou T, Rufer C, Lytrivi M, Bosi E, Burdet F, Fantuzzi F, De Luca C, Sebastiani G, Saponaro C, Pugliese L A, Del Guerra S, Pocai A, De Simone P, Ghinolfi D, Boggi U, Kessler C, Grieco G E, Fignani D, Kerr-Conte J, Pattou F, Nacher M, Montanya E, Mourad N, Buemi A, Citi V, Martelli A, Benedetti G, Calderone V, Rossi L, Paolicchi A, Cardarelli F, Dotta F, Eizirik D L, Ibberson M, Marchetti P, Cnop M, Marselli L.
Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches
Science Advances 2025.
Nasiri R, Madadelahi M, Nikmaneshi M R, Gokce B, Bijarchi M A, Shah S, Tirpáková Z, Van Gastel D, Taebnia N, de Barros N R, Zhu Y, Morcimen Z G, Gulicli B, Habibey R, Sendemir A, Jain S, Enrico A, Lauschke V M, Dokmeci MR, Pratx G, Khademhosseini A, Herland A.
Engineering biomimetic tissue barrier models on chips: From design and fabrication to applications in disease modeling and drug screening
Biomaterials 2025.
Gugescu L, Yang Y, Fabienne Kool J, Fyhrquist N, Wincent E, Alenius H.
Microbiota modulates compound-specific toxicity of environmental chemicals: A multi-omics analysis in zebrafish embryos
Environment International 2025.
Tzoupis H, Papadourakis M, Papavasileiou K, Burk O, Lauschke V, Tsoumanis A, Melagraki G, Afantitis A.
Assessment of the Binding Patterns for Endocrine Disrupting Chemicals in Complex with Estrogen and Androgen Receptors by Leveraging the Asclepios Enalos KNIME Node
Journal of Chemical Information and Modeling 2025.
Bustamante CM, Ruiz P, Rifat AB, Bravo N, Grimalt JO, Gari M.
Methodological approach for a simultaneous determination of persistent and non-persistent organic pollutants in human blood (serum/plasma) using gas chromatography and mass spectrometry techniques
Journal of Chromatography A 2025.
Heikkinen T, Küblbeck J, Rysä J.
Metabolic disruption by mycotoxins: focus on metabolic endpoints steatosis, adipogenesis and glucose metabolism in vivo and in vitro
Arch Toxicol 2025.
Gogola T, Pitkänen S, Huovinen M, Laitinen H, Küblbeck J.
Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – Systematic literature review
Environ Res 2025.
Lytrivi M, Tong Y, Virgilio E, Yi X, Cnop M.
Diabetes mellitus and the key role of endoplasmic reticulum stress in pancreatic β cells
Nat Rev Endocrinol 2025.
Hukkanen J, Küblbeck J, Hakkola J, Rysä J.
Nuclear receptors CAR and PXR as cardiometabolic regulators
Pharma Res 2025.
Swan J, Zhurenko D, Huttunen KM, Rysä J.
Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects
Arch Toxicol 2025.
Moghazy M, Papathanasiou M, Tzoupis H, Papavasileiou KD, Zing C, Lauschke VM, Afantitis A, Melagraki G.
A systematic literature review of reproductive toxicological studies on phthalates
Int J Mol Sci 2025.
Hakomäki H, Pitkänen S, Levonen A-L, Honkakoski P, Greco D, D’Alessandro N, Saarimäki LA, Viegas S, Godinho C, Fyhrquist N, Wincent E, Lauschke VM, Hukkanen J, Hakkola J, Vallier L, Fortino V, Afantitis A, Sawatani T, Guzman TJ, Cnop M, Nawrot T, Harlid S, Vinnars M-T, Tardon A, Grimalt JO, Küblbeck J, Rysä J.
Unmasking metabolic disruptors: The NEMESIS project’s quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies
Open Research Europe 2025.
Bustamante CM, Polanska K, Jankowska A, Jerzynska J, Grimalt J, Garí M.
In-depth screening of pesticide exposure in children from urban and agricultural settings in Poland
Science of The Total Environment 2025.
Bustamante CM, Bravo N, Ruiz P, Grimalt JO, Garí M.
Method optimization for a simultaneous determination of neonicotinoid, carbamate/thiocarbamate, triazole, organophosphate and pyrethroid pesticides and their metabolites in urine using UPLC-MS/MS
Journal of Chromatography A 2024.