Exciting Research Highlights from 2025
The year 2025 has been both busy and successful one for the NEMESIS project. Our team has published several new studies in leading scientific journals, providing new insights into metabolic disruption, the effects of environmental chemicals, and innovative methodologies for assessing their potential adverse health effects.
Highlights from this year’s publications:
🎄 Get to know NEMESIS: Take a closer look at the project’s overall mission to uncover metabolic disruptors and develop improved methods and tools in Hakomäki et al. Unmasking metabolic disruptors: The NEMESIS project’s quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies. Open Research Europe, 2025.
🎄 Endocrine disruption and receptor binding: Step inside the molecular world of estrogen and androgen receptors as we map how endocrine disruptors interact with these key targets using advanced computational tools. Tzoupis et al. Assessment of the Binding Patterns for Endocrine Disrupting Chemicals in Complex with Estrogen and Androgen Receptors by Leveraging the Asclepios Enalos KNIME Node. Journal of Chemical Information and Modeling, 2025.
🎄 Mycotoxins and metabolic health: Explore how common mycotoxins influence steatosis, adipogenesis, and glucose metabolism in our comprehensive review on compiling data from in vivo and in vitro studies. Heikkinen et al. Metabolic disruption by mycotoxins: focus on metabolic endpoints steatosis, adipogenesis and glucose metabolism in vivo and in vitro. Archives of Toxicology, 2025.
🎄 Phthalates and liver health: Unwrap the current evidence linking phthalate exposure to MASLD and get a clearer picture of how these chemicals may shape metabolic liver disease. Gogola et al. Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – Systematic literature review. Environmental Research, 2025.
🎄 ER stress and diabetes: Learn what we found out about the central role of endoplasmic reticulum stress in pancreatic β-cell function and its contribution to diabetes. Lytrivi et al. Diabetes mellitus and the key role of endoplasmic reticulum stress in pancreatic β cells. Nature Reviews Endocrinology, 2025.
🎄Tracking organic pollutants: This methodological paper presents a streamlined approach for measuring both persistent and non-persistent organic pollutants in human blood using advanced chromatographic and mass spectrometric techniques. Bustamante et al. Methodological approach for a simultaneous determination of persistent and non-persistent organic pollutants in human blood (serum/plasma) using gas chromatography and mass spectrometry techniques. Journal of Chromatography A, 2025.
🎄 Children’s pesticide exposure: How do the pesticide exposure patterns look in Polish children growing up in busy cities or fertile agricultural regions? Important environmental health trends revealed. Bustamante et al. In-depth screening of pesticide exposure in children from urban and agricultural settings in Poland. Science of The Total Environment, 2025.
🎄 Nuclear receptors and cardiometabolic health: Discover how the nuclear receptors CAR and PXR influence cardiometabolic processes, highlighting their emerging importance in metabolic research. Hukkanen et al. Nuclear receptors CAR and PXR as cardiometabolic regulators. Pharmacological Research, 2025.
🎄 Placental thyroid signalling: Take a detailed look at how chemicals can disrupt placental thyroid hormone pathways, often in sex-specific ways, with implications for early developmental health. Swan et al. Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects. Archives of Toxicology, 2025.
🎄 Phthalates and reproductive health: Check out the comprehensive review of how phthalates impact reproductive systems, helping clarify risks and research gaps. Moghazy et al. A systematic literature review of reproductive toxicological studies on phthalates. International Journal of Molecular Sciences, 2025.
See the research publications HERE.
As we head into a new year of discovery, the NEMESIS team extends warm holiday wishes to all of you. May your days be merry, bright, and free from metabolic disruptors!
